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Cysteine Proteinase (Cp- 30) Protein of Trichomonas Vaginalis



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CP30 protein plays an important role in the establishment of host parasite relationship in Trichomoniasis. In the present work, single letter amino acid sequence of CP30 protein of T. vaginalis (ACC.No.NP_057852) was retrieved from protein database of NCBI, taken as a target protein sequence. Modeling of 3D structure of CP30 protein performed related to the target sequence using PSI-BLAST.As a consequence of number of hits, potential template structure (PDB-ID: 1K30), followed by calculation for energy and root mean square deviation (RMSD) of the specific model. Subsequently, various inhibitors were docked employing AutoDock to CP30 protein structure determined by comparative homology modeling. Auto Dock 3.05' was used for docking and calculation of the energy maps. From inhibitor optimization and docking studies, suitable inhibitor sphingosine is hunted. CP30 binds by the designed inhibitor; it may be very successful drug for CP30 protein inhibition. This work on inhibitor optimization will be a platform for the further studies on molecular mechanism of HIV infection & for most cost effective drug designing & for finding the inhibitor against this sexual transmitting disease.






CP30 protein plays an important role in the establishment of host parasite relationship in Trichomoniasis. In the present work, single letter amino acid sequence of CP30 protein of T. vaginalis (ACC.No.NP_057852) was retrieved from protein database of NCBI, taken as a target protein sequence. Modeling of 3D structure of CP30 protein performed related to the target sequence using PSI-BLAST.As a consequence of number of hits, potential template structure (PDB-ID: 1K30), followed by calculation for energy and root mean square deviation (RMSD) of the specific model. Subsequently, various inhibitors were docked employing AutoDock to CP30 protein structure determined by comparative homology modeling. Auto Dock 3.05' was used for docking and calculation of the energy maps. From inhibitor optimization and docking studies, suitable inhibitor sphingosine is hunted. CP30 binds by the designed inhibitor; it may be very successful drug for CP30 protein inhibition. This work on inhibitor optimization will be a platform for the further studies on molecular mechanism of HIV infection & for most cost effective drug designing & for finding the inhibitor against this sexual transmitting disease.


vaginalis encodes for a 42.8 kDa precursor cysteine proteinase of the legumain type dubbed TvLEGU11. 10 20 30 40 50 MFVQQHEQKA FLSWMRETGN MFTGEEYQTR LGIWLSNKRL VQEHNRANLG 60 70 80. Compre Cysteine proteinase cp 30 protein of trichomonas vaginalis no Soubarato. Insilico Homology Modeling and Docking study.


Cp Protein

Cysteine Proteinase Cp 30 Protein of Trichomonas Vaginalis from Dymocks online bookstore. MolecBiochemParasitol 542. CP30 a cysteine proeinase involved in Trichomonas vaginalis cytoadherence. by M Yadav 2007 Cited by 27 Infection with Trichomonas vaginalis may be asymptomatic or with symptoms suggestive of vaginitis. To identify the TvLEGU1 CP in T. 2009 Glyceraldehyde3phosphate dehydrogenase is a surfaceassociated fibronectinbinding protein of Trichomonas vaginalis. vaginalis is known to be a virulence marker that plays a role in cytoadherence the aim of this study was to analyse the presence of CP30 and antibody to Infection with Trichomonas vaginalis may be asymptomatic or with symptoms suggestive of vaginitis. A cysteine proteinase of 30 kDa CP30 of Trichomonas vaginalis is known to play a role in cytoadherence of the parasite to host cells. vaginalis cysteine proteinases characterized to date belong to families C1 and C13 . The goal of this paper was to characterize a Trichomonas vaginalis cysteine proteinase CP legumain1 TvLEGU1 and determine its potential role as a virulence factor during T. Trichomonas vaginalis is an anaerobic flagellated protozoan parasite and the causative agent of trichomoniasis.


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